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蝎氯毒素-Chlorotoxin
簡(jiǎn)要描述：Smartox Biotechnology是*一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細胞離子通道功能研究的生物醫藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號：08CHL001- 廠(chǎng)商性質(zhì)：代理商
- 更新時(shí)間：2024-03-26
- 訪(fǎng) 問(wèn) 量：1850
產(chǎn)品介紹
Chlorotoxin（蝎氯毒素 氯代毒素）
Selective ligand of Glioma cells(神經(jīng)膠質(zhì)瘤細胞的選擇性配體)
Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl-channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl- channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells making chlorotoxin a promising antitumoral drug and diagnosis tool.
Chlorotoxin 技術(shù)資料
氨基酸序列：
Met-Cys2-Met-Pro-Cys5-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys16-Asp-Asp-Cys19-Cys20-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys28-Tyr-Gly-Pro-Gln-Cys33-Leu-Cys35-Arg-NH2
二硫鍵：Cys2-Cys19, Cys5-Cys28, Cys16-Cys33 and Cys20-Cys35
長(cháng)度 (aa)： 36
分子式： C158H249N53O47S11
分子量： 3995.8 Da
外觀(guān)：White lyophilized solid
可溶性：water and saline buffer
CAS 號：[163515-35-3]
來(lái)源：Synthetic
純度：> 95 %
產(chǎn)品信息
08CHL001-00100 | Chlorotoxin | 0.1mg |
08CHL001-00200 | Chlorotoxin | 0.2mg |
08CHL001-00500 | Chlorotoxin | 0.5mg |
08CHL001-01000 | Chlorotoxin | 1mg |
