產(chǎn)品介紹

AdTx1 (rho-Da1a – ρ-Da1b)

Selective antagonist of the alpha(1A)-adrenoceptor

腎上腺受體alpha(1A)選擇性拮抗劑

AdTx1 (rho-Da1a – ρ-Da1b) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1is a potent relaxant of smooth muscles.

AdTx1 (rho-Da1a – ρ-Da1b)技術(shù)資料

氨基酸序列：

LTC³VTSKSIFGITTEDC¹⁷PDGQNLC²⁴FKRRHYVVPKIYDSTRGC⁴²AATC⁴⁶PIPENYDSIHC⁵⁷C⁵⁸KTDKC⁶³NE

二硫鍵： Cys³-Cys²⁴, Cys¹⁷-Cys⁴², Cys⁴⁶-Cys⁵⁷, Cys⁵⁸-Cys⁶³

長(cháng)度 (aa)： 65

分子式：C₃₁₀H₄₈₁N₈₇O₁₀₀S₈

分子量（平均）：7283.29 Da

外觀(guān)：White lyophilized solid

可溶性：water and saline buffer

CAS 號：not available

來(lái)源：Synthetic

純度：> 98%

產(chǎn)品信息

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